Parasitic Helminths / Drug Discovery in Infectious Diseases Bd.3 (PDF)

Foreword (Peter Hotez) Preface TARGETS Ligand gated Ion channels as targets for anthelmintic drugs: past, current and future perspectives (Kristin Lees, Ann Sluder, Niroda Shannan, Lance Hammerland and David Sattelle) How relevant is caenorhabditis elegans as a model for the analysis of parasitic nematode biology? (Lindy Holden-Dye and Robert J Walker) Integrating and mining helminth genomes to discover and prioritize novel therapeutic targets (Dhanasekaran Shanmugam, Stuart A Ralph, Santiago J Carmona,Gregory J Crowther, David S Roos and Fernán Agüero) Recent progress in transcriptomics of key gastrointestinal nematodes of animals: fundamental research toward new intervention strategies (Cinzia Cantacessi, Bronwyn E. Campbell, Aaron R. Jex, Ross S. Hall, Neil D. Young, Matthew J. Nolan, Robin B. Gasser) Harnessing genomic technologies to explore the molecular biology of liver flukes - major implications for fundamental and applied research (Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Bronwyn E. Campbell and Robin B. Gasser) RNA Interference: A potential discovery tool for therapeutic targets of parasitic nematodes (Collette Britton) RNA Interference as a tool for drug discovery in parasitic flatworms (Akram A. Da'dara and Patrick J. Skelly) SCREEN Mechanism-based screening strategies for anthelmintic discovery (Timothy G. Geary) Identification and profiling of nematicidal compounds in veterinary parasitology (Andreas Rohwer, Jürgen Lutz , Christophe Chassaing, M. Uphoff, AR Heckeroth, Paul Selzer) Quantitative high-content screening-based drug discovery against helmintic diseases (Rahul Singh) Use of rodent models in the discovery of novel anthelmintics (Rebecca Fankhauser, Linsey R. Cozzie, Bakela Nare, Kerrie Powell, Ann E. Sluder and Lance G. Hammerland) To kill a mocking worm: Strategies to improve Caenorhabditis elegans as a model system for use in anthelmintic discovery (Andrew R. Burns and Peter J. Roy) DRUGS Anthelmintic drugs: Tools and shortcuts for

Volume editor:
Conor R. Caffrey completed his Ph.D. thesis research in 1993 at University College Dublin. He then moved to the Department of Tropical Medicine and Hygiene at the University of Heidelberg as a Wellcome Trust Travelling Research Scholar. Between 1998 and 2000, he was a post-doctoral scholar at the Department of Pathology of the University of California San Francisco. After a brief faculty appointment at the University of Wales, Aberystwyth, Dr. Caffrey returned to UCSF in 2001 to direct the Biochemistry and Molecular Parasitology Core of the Sandler Center the Sandler Center for Basic Research in Parasitic Diseases (now the Sandler Center for Drug Discovery). Dr. Caffrey?s current research focus is pre-clinical drug discovery for tropical infectious diseases, particularly schistosomiasis and African trypanosomiasis.

Series Editor:
Prof. Dr. Paul M. Selzer studied Biology, Parasitology, and Biochemistry at the University of Tübingen, Germany, where he also received his PhD in Biochemistry on subjects related to the protozoan parasite Trypanosoma brucei. As a post-doctoral fellow he spent three years in the parasitology and tropical disease laboratory of Prof. James H. McKerrow at the University of California, San Francisco (UCSF). Within the Molecular Design Institute at UCSF Dr. Selzer was introduced to modern drug discovery approaches and technologies. He broadened his scientific and business knowledge as a researcher within diverse pharmaceutical companies including Boehringer Mannheim GmbH, Germany, SmithKline Beecham p.l.c., UK, Hoechst Roussel Vet GmbH, Germany, and finally Intervet Innovation GmbH, Germany, a part of Intervet/Schering-Plough Animal Health. Dr. Selzer is also a teacher in Biochemistry, Bioinformatics, and Chemoinformatics at the University of Tübingen in the Department of Biochemistry, which awarded him the title of Professor for his achievements in teaching and research. In 2008, he was also awarded an Honorary Professorship

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