PARP Inhibitors for Cancer Therapy / Cancer Drug Discovery and Development (PDF)
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PARP Inhibitors for Cancer Therapy provides a comprehensive overview of the role of PARP-poly ADP ribose polymerase-in cancer therapy. The volume covers the history of the discovery of PARP and its role in DNA repair. Additionally, it describes the discovery of the PARP family, and includes a discussion of other DNA maintenance-associated PARPs. As well, the volume features a section on the accessible chemistry behind the development of inhibitors.
PARP inhibitors-PARPi-are a group of pharmacological inhibitors that are particularly good targets for cancer therapy. PARP plays a pivotal role in DNA repair and may contribute to the therapeutic resistance to DNA-damaging agents used to treat cancer. Researchers have learned a great deal about the biology of PARP and how tumor-specific defects in DNA repair can be exploited by PARPi. The "synthetic lethality" of PARPi is an exciting concept for cancer therapy, and has led to heightened activity in this area.
Ricky Sharma is Associate Professor at the University of Oxford and Honorary Consultant in Clinical Oncology at the Oxford University Hospitals NHS Trust. He graduated in medicine from the University of Cambridge, and subsequently trained in toxicology, general internal medicine, medical oncology and clinical oncology in Cambridge, Glasgow, Leicester and London. Since 2006, he has led a translational research group at the University of Oxford focussed on DNA damage repair and the development of new chemotherapy and radiotherapy treatments for cancer.
- 2015, 2015, 591 Seiten, Englisch
- Herausgegeben: Nicola J. Curtin, Ricky A. Sharma
- Verlag: Springer-Verlag GmbH
- ISBN-10: 3319141511
- ISBN-13: 9783319141510
- Erscheinungsdatum: 13.06.2015
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- Größe: 15 MB
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