Pharmacogenomics of Human Drug Transporters (ePub)

Sets the foundation for safer, more effective drug
therapies

With this book as their guide, readers will discover how to
apply our current understanding of the pharmacogenomics of drug
transporters to advance their own drug discovery and development
efforts. In particular, the book explains how new findings in the
field now enable researchers to more accurately predict drug
interactions and adverse drug reactions. Moreover, it sets the
foundation for the development of drug therapies that are tailored
to an individual patient's genetics.

Pharmacogenomics of Human Drug Transporters serves as a
comprehensive guide to how transporters regulate the absorption,
distribution, and elimination of drugs in the body as well as how
an individual's genome affects those processes. The book's eighteen
chapters have been authored by a team of leading pioneers in the
field. Based on their own laboratory and clinical experience as
well as a thorough review of the literature, these authors explore
all facets of drug transporter pharmacogenomics, including:

* Individual drug transporters and transporter families and their
clinical significance

* Principles of altered drug transport in drug-drug
interactions, pharmacotherapy, and personalized medicine

* Emerging new technologies for rapid detection of genetic
polymorphisms

* Clinical aspects of genetic polymorphisms in major drug
transporter genes

* Future research directions of drug transporter pharmacogenomics
and the prospect of individualized medicine

Pharmacogenomics of Human Drug Transporters opens the
door to new drug discovery and development breakthroughs leading to
safer and more effective customized drug therapies.The book is
recommended for pharmaceutical scientists, biochemists,
pharmacologists, clinicians, and genetics and genomics
researchers.