The Chemical Biology of DNA Damage (PDF)

Preface PART I: Chemistry and Biology of DNA Lesions INTRODUCTION AND PERSPECTIVES ON THE CHEMISTRY AND BIOLOGY OF DNA DAMAGE Overview of the Field DNA Damage ¿ A Constant Threat DNA Damage and Disease DNA Damage and Chemotherapeutic Applications The Cellular DNA Damage Response (DDR) Repair Mechanisms that Remove DNA Lesions Relationships between the Chemical, Structural, and Biological Features of DNA Lesions CHEMISTRY OF INFLAMMATION AND DNA DAMAGE: BIOLOGICAL IMPACT OF REACTIVE NITROGEN SPECIES Introduction DNA Oxidation and Nitration DNA Deamination 2¿-Deoxyribose Oxidation Indirect Base Damage Caused by RNS Conclusions OXIDATIVELY GENERATED DAMAGE TO ISOLATED AND CELLULAR DNA Introduction Single Base Damage Tandem Base Lesions Hydroxyl Radical-Mediated 2-Deoxyribose Oxidation Reactions Secondary Oxidation Reactions of Bases Conslusions and Perspectives ROLE OF FREE RADICAL REACTIONS IN THE FORMATION OF DNA DAMAGE Introduction Importance of Free Radical Reactions with DNA Mechanisms of Product Formation Biological Implications DNA DAMAGE CAUSED BY ENDOGENOUSLY GENERATED PRODUCTS OF OXIDATIVE STRESS Lipid Peroxidation 2¿-Deoxyribose Peroxidation Reactions of MDA and Beta-Substituted Acroleins with DNA Bases Stability of M1dG: Hydrolytic Ring-Opening and Reaction with Nucleophiles Propano Adducts Etheno Adducts Mutagenicity of Peroxidation-Derived Adducts Repair of DNA Damage Assessment of DNA Damage Conclusions POLYCYCLIC AROMATIC HYDROCARBONS: MULTIPLE METABOLIC PATHWAYS AND THE DNA LESIONS FORMED Introduction Radical Cation Pathway Diol Epoxides PAH o-Quinones Future Directions AROMATIC AMINES AND HETEROCYCLIC AROMATIC AMINES: FROM TOBACCO SMOKE TO FOOD MUTAGENS Introduction Exposure and Cancer Epidemiology Enzymes of Metabolic Activation and Genetic Polymorphisms Reactivity of N-Hydroxy-AAs and N-Hydroxy-HAAs with DNA Synthesis of AA-DNA and HAA-DNA Adducts Biological Effects of AA-DNA and HAA-DNA Adducts Biological Effects of AA-DNA and HAA-DNA Adducts

Nicholas E. Geacintov is Professor of Chemistry and former Chair of the Department of Chemistry at New York University (NYU), USA. He received his PhD degree in physical chemistry and polymer chemistry from the State University of New York College of Forestry at Syracuse University, and spent most of his career at NYU. His current research interests are focused on the mechanisms of chemical carcinogenesis and oxidatively generated DNA damage, especially the relationships between the structural features of DNA lesions and their impact on DNA repair and replication. He has published over 350 papers and is currently serving as a member of the Editorial Board of the Journal of Biological Chemistry.

Suse Broyde is Professor of Biology and Affiliate Professor of Chemistry at New York University, USA. Her research interests are focused on computer modeling of DNA lesions, with the goal of elucidating the molecular origins of their mutagenic and tumorigenic properties. She holds a PhD degree in physical chemistry with a minor in physics from the Polytechnic Institute of New York, and has published over 160 papers in peer-reviewed journals. She has been a member of the Editorial Advisory Board of Chemical Research in Toxicology.

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