Tuning Autophagy-Inducing Activity and Toxicity for Lanthanide Nanocrystals / Springer Theses (PDF)
(Sprache: Englisch)
This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that...
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This thesis presents a simple, yet highly effective surface engineering solution that uses non-covalent binding peptides to control the autophagy-inducing activity of nanomaterials and nanodevices. The author presents RE-1, a short synthetic peptide that sequence-specifically binds to lanthanide (LN) oxide and upconversion nanocrystals with high affinity, which was discovered using an innovative phage display approach. RE-1 effectively inhibits the autophagy-inducing activity and toxicity of these nanocrystals by forming a stable coating layer on the surface of the nanoparticles, and by reducing their sedimentation and cell interaction. RE- 1 and its variants provide a versatile tool for tuning cell interactions in order to achieve the desired level of autophagic response and are useful for the various diagnostic and therapeutic applications of LN-based nanomaterials and nanodevices.
Autoren-Porträt von Yunjiao Zhang
Bibliographische Angaben
- Autor: Yunjiao Zhang
- 2022, 1st ed. 2022, 156 Seiten, Englisch
- Verlag: Springer Nature Singapore
- ISBN-10: 981168166X
- ISBN-13: 9789811681660
- Erscheinungsdatum: 09.01.2022
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- Größe: 5.21 MB
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Englisch
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