Insights into Receptor Function and New Drug Development Targets

Name: Insights into Receptor Function and New Drug Development Targets
Brand: Springer, Berlin, Springer, Springer Berlin Heidelberg
SKU: 19404463
Price: 109.99 EUR
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(Sprache: Englisch)

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Produktbeschreibung
Inhaltsverzeichnis
Biblio. Angaben / Produktdetails

Produktinformationen zu „Insights into Receptor Function and New Drug Development Targets “

This book describes the current state of knowledge in receptor function in the development of new drugs. Science is on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The book reviews the availability of state-of-the-art tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

Klappentext zu „Insights into Receptor Function and New Drug Development Targets “

We are now on the verge of viewing effector molecules and other regulatory sites as therapeutic targets for the amelioration of human and animal disease. The recognition, for example, that mutant proteins are frequently misrouted molecules, rather than functionally defective ones, changes our approach to "inborn errors of metabolism" and offers new approaches for pharmacological discovery, based on rescue of receptors, ion channels and enzymes with pharmacoperones. Ion channels, regulators of G-protein signaling and enzymes engaged in regulation, now present opportunities for drug development.

The state of our art also benefits by the availability of superior tools that allow measurement of interactions and afford unprecedented insight into the biomolecular interactions that present novel approaches to drug design.

Inhaltsverzeichnis zu „Insights into Receptor Function and New Drug Development Targets “

Molecular and functional diversity of the TRPC family of ion channels. TRPC channels and their role in ROCE/SOCE.- Functional Rescue of Misfolded Receptor Mutants.- Obesity-related mutations of leptin and melanocortin receptors.- cAMP- and cGMP-dependent control of lipolysis and lipid mobilization in humans: putative targets for fat cell management.- Central Neuropeptide Receptors Involved in Water Balance: Application to Apelin.- Targeting regulators of G protein signaling (RGS proteins) to enhance agonist specificity.- Dimeric GPCRs: what did we learn from the metabotropic glutamate receptors?.- Guiding principles applied in the design of GPCR-selective hypothalamic hormone agonists and antagonists.- Mutations in G proteins and G protein-coupled receptors in human endocrine diseases.- A molecular dissection of the glycoprotein hormone receptors.- Receptor Tyrosine Kinases as Targets for Cancer Therapy Development.- Targets for pituitary tumor therapy.- The endogenous cannabinoid system in the control of food intake and energy balance.

Bibliographische Angaben

2006, XV, 202 Seiten, Maße: 15,9 x 24,4 cm, Gebunden, Englisch
Herausgegeben: P. Michael Conn, Claude Kordon
Verlag: Springer, Berlin
ISBN-10: 3540344462
ISBN-13: 9783540344469
Erscheinungsdatum: 25.07.2006

Sprache:

Englisch

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